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KMID : 0358320090500050457
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Korean Journal of Urology
2009 Volume.50 No. 5 p.457 ~ p.462
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Oncological and Surgical Outcomes of Pure Laparoscopic Radical Nephrectomy and Hand-Assisted Laparoscopic Radical Nephrectomy for pT1 Renal Cell Carcinoma: Comparison with Open Radical Nephrectomy
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Kim Myong
Park Yong-Hyun
Lee Sang-Eun
Kwak Cheol
Kim Hyeon-Hoe
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Abstract
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Purpose: We compared the surgical and oncologic outcomes of pure laparoscopic radical nephrectomy (PLRN) and hand-assisted laparoscopic radical nephrectomy (HLRN) with those of open radical nephrectomy (ORN) in patients with pT1 renal cell carcinoma (RCC).
Materials and Methods: Between 1999 and 2007, a total of 269 patients underwent PLRN (n=77), HLRN (n=87), and ORN (n=105) for pT1 RCC. Follow-up data consisted of clinical, pathologic, and oncologic results and were reviewed retrospectively. Kaplan-Meier survival curves were constructed for progression and survival endpoints.
Results: Mean operative time was 184.0, 164.0, and 132.6 minutes (p＜ 0.001); mean estimated blood loss was 196.7, 147.8, and 232.6 ml (p＜0.001); and mean postoperative hospital stay was 5.7, 7.2, and 7.8 days (p＜0.001) for the PLRN, HLRN and ORN groups, respectively. The major complication rate after surgery was 2.6%, 2.3%, and 3.8%, respectively (p=0.807). Median follow-up periods were 32 months in the PLRN group, 48 months in the HLRN group, and 37 months in the ORN group. Five-year progression-free survival was 97.4%, 96.6%, and 98.1% (p=0.557), and 5-year cancer-specific survival was 98.7%, 96.6%, and 98.1% (p=0.508), respectively.
Conclusions: PLRN and HLRN are safe treatment options with comparable oncologic results to ORN for pT1 RCC.
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KEYWORD
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Renal cell carcinoma, Nephrectomy, Laparoscopic surgery, Treatment outcome
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